The bioavailability of some orally administered botanical extracts is erratic and poor due to limited gastro-intestinal absorption.
Bioavailability can be improved by using new delivery systems which can enhance the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes.
Phospholipids exhibit a marked affinity for polyphenols. By complexing
the polyphenolic phytoconstituents in a molar ratio with phosphatidylcholine, Indena has developed a new series of non-covalent supramolecular adducts named “Phytosome^®s”.
Phytosome^®s show better pharmacokinetic and therapeutic profile than their non-complexed herbal extract.
The Phytosome^®s technology, markedly enhances the bioavailability
of selected phytochemicals.

1. Paris M. Kidd,”Bioavailability and Activity of Phytosome Complexes from Botanical: The Silymarin, Curcumin, Grean Tea, and Grape Seed Extracts”, Alternative Medicine Review, Vol. 14, N. 3 (2009)
2. Semalty A., Semalty S., Rawat, Francesci F., "Supramolecular phospholipids-polyphenolics interactions: the Phytosome® strategy to improve bioavailability of phytochemicals", Fitoterapia, in press

 

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